Construction of ratiometric fluorescent sensors by ribonucleopeptides.
نویسندگان
چکیده
Ratiometric fluorescent sensors were constructed from RNA aptamers by generating modular ribonucleopeptide complexes. Fluorescent ribonucleopeptides containing fluorophore seminaphthorhodafluor tethered to their peptide subunit revealed a dual emission property, which permitted a ratiometric fluorescent measurement of a substrate-binding event. The strategy successfully afforded ratiometric fluorescent sensors for biologically active small ligands, tetracycline, dopamine and streptomycin.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 44 شماره
صفحات -
تاریخ انتشار 2012